Intermingled skin grafts with in vitro cultured keratinocytes--experiments with rats

In vitro cultured autogenic keratinocytes were used instead of autogenic skin islets in intermingled skin grafts on rats. According to the observations made with the original method, the allogenic epidermis is being rejected. The cultured keratinocytes start to grow out in circles, eventually covering the remaining allodermis in the form of a multilayered, well-differentiated epidermis. The prospects of these findings for possible future clinical applications are discussed.