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Related Concept Videos

Atherosclerosis I: Introduction01:30

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Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
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Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

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Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
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Related Experiment Video

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Quantification of Atherosclerosis in Mice
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Genetic experimental preparations for studying atherosclerosis.

Sheila E Francis1

  • 1Department of Cardiovascular Science, Medical School, University of Sheffield, Sheffield, United Kingdom.

Progress in Molecular Biology and Translational Science
|April 23, 2014
PubMed
Summary

Atherosclerosis, a slow-developing arterial disease, has been studied using traditional methods for decades. Current experimental models are reaching their limits, necessitating novel approaches to fully understand its complex biology.

Keywords:
AtherosclerosisGene targetingMousePorcineZebrafish

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Area of Science:

  • Cardiovascular Biology
  • Pathology
  • Experimental Medicine

Background:

  • Atherosclerosis is a chronic inflammatory disease contributing to coronary artery disease, morbidity, and mortality.
  • Decades of research using cellular, animal, and human models have advanced understanding of atherosclerosis biology.
  • Current gene-targeted experimental preparations are nearing their research capacity.

Purpose of the Study:

  • To highlight the limitations of existing experimental models in atherosclerosis research.
  • To emphasize the need for innovative experimental preparations to address remaining questions in atherosclerosis biology.

Main Methods:

  • Review of established experimental approaches in atherosclerosis research.
  • Analysis of the current limitations of gene-targeted experimental models.

Main Results:

  • Standard experimental preparations for studying atherosclerosis are becoming insufficient.
  • Further advancements in understanding atherosclerosis require new methodologies.

Conclusions:

  • The field of atherosclerosis biology requires the development of novel experimental preparations.
  • Overcoming current research limitations is crucial for future breakthroughs in preventing and treating atherosclerosis.