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Updated: May 1, 2026

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis

Published on: November 12, 2015

Corneal collagen crosslinking: a systematic review.

Nir Sorkin¹, David Varssano

¹Department of Ophthalmology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

Ophthalmologica. Journal International D'Ophtalmologie. International Journal of Ophthalmology. Zeitschrift Fur Augenheilkunde

|April 23, 2014

Summary

Corneal crosslinking (CXL) strengthens corneas by using riboflavin and UV light to create crosslinks, effectively treating keratoconus and other ectatic disorders. This established procedure enhances corneal biomechanics and visual outcomes.

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Area of Science:

Ophthalmology
Corneal Ectasia Research
Biomaterials Science

Background:

Keratoconus (KCN) and other ectatic disorders cause progressive corneal thinning and visual deterioration.
Current treatments aim to halt disease progression and improve vision.

Purpose of the Study:

To provide a comprehensive review of corneal crosslinking (CXL).
To discuss CXL's biomechanical principles, protocol evolution, indications, efficacy, and safety.

Main Methods:

Review of existing literature on corneal crosslinking (CXL).
Analysis of CXL's mechanism, historical development, and current applications.
Evaluation of treatment outcomes and safety profiles.

Main Results:

CXL effectively arrests the progression of KCN, post-LASIK ectasia (PLE), and pellucid marginal degeneration (PMD).
CXL demonstrates efficacy in treating corneal infections, chemical burns, and edema.
The procedure enhances corneal biomechanics by increasing stromal stiffness.

Conclusions:

Corneal crosslinking is an established and effective treatment for various corneal ectatic disorders.
CXL offers a safe and viable therapeutic option for managing corneal pathologies and improving visual function.