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Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents
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How does stress possibly affect cardiac remodeling?

Dejana Popovic1, Bosiljka Plecas-Solarovic2, Vesna Pesic2

  • 1Division of Cardiology, Faculty of Medicine, University of Belgrade, Visegradska 26, 11000 Belgrade, Serbia.

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|April 23, 2014
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Summary
This summary is machine-generated.

Adrenocorticotropic hormone (ACTH) and its receptor polymorphism (ACTHRP) significantly predict cardiac morphology, including left ventricular mass and volume. These findings suggest the stress system plays a key role in cardiac remodeling.

Keywords:
Adrenocorticotropic hormoneAdrenocorticotropic hormone receptor polymorphismCortisolLeft ventricular remodelingStress

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Area of Science:

  • Cardiology
  • Endocrinology
  • Genetics

Background:

  • The stress system, involving adrenocorticotropic hormone (ACTH) and cortisol, influences cardiovascular health.
  • Genetic variations in the ACTH receptor (ACTHRP) may modulate individual responses to stress and cardiac remodeling.
  • Elite athletes serve as models for chronic stress adaptation, allowing investigation of stress markers and cardiac structure.

Purpose of the Study:

  • To evaluate the predictive value of ACTH, cortisol, and ACTH receptor polymorphism (ACTHRP) for left ventricular (LV) remodeling.
  • To compare cardiac parameters and stress hormone levels between elite athletes and sedentary individuals.
  • To investigate the association between ACTHRP genotypes and cardiac morphology.

Main Methods:

  • Echocardiography (standard and tissue Doppler) assessed cardiac parameters at rest in 36 elite male athletes and 20 sedentary controls.
  • Maximal cardiopulmonary exercise tests served as acute stress models.
  • ACTH and cortisol levels were measured at rest, during peak exercise, and during recovery; ACTHRP was analyzed using polymerase chain reaction and restriction fragment length polymorphism analysis.

Main Results:

  • Both ACTH and cortisol increased during acute stress, with ACTH remaining elevated in recovery.
  • Left ventricular mass (LVM) and end-diastolic volume (LVVd) were significantly higher in athletes than controls.
  • ACTH at rest and ACTHRP genotype were strong independent predictors of LVM and LVVd, with specific genotypes showing differences in cardiac morphology.

Conclusions:

  • ACTH levels at rest and ACTH receptor polymorphism are significant predictors of cardiac morphology, specifically left ventricular mass and volume.
  • These findings highlight a potential regulatory role for the activity and sensitivity of the stress system in cardiac remodeling.
  • The study suggests that individual differences in stress system components can influence cardiac structural adaptations.