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[Association between CISH polymorphisms and susceptibility to chronic hepatitis B in Chinese Han population]

Xin Zhang1, Xuehua Sun, Zhenhua Zhou

  • 1Department of Hepatology, Shuguang Hospital Affiliated of Shanghai Traditional Chinese Medicine University, Clinical Key Laboratory of Traditional Chinese Medicine, Shanghai 201203, China.E-mail: zhangxin68619@163.com.

Nan Fang Yi Ke Da Xue Xue Bao = Journal of Southern Medical University
|April 23, 2014
PubMed

Insights

The cytokine-inducible Src homology 2 domain protein (CISH) rs414171 single nucleotide polymorphism (SNP) is not linked to chronic hepatitis B risk in the Chinese Han population. This genetic variant does not appear to influence susceptibility to this common liver disease.

Area of Science:

  • Genetics
  • Immunology
  • Hepatology

Background:

  • Chronic hepatitis B is a significant global health concern.
  • Genetic factors play a role in hepatitis B virus (HBV) infection susceptibility.
  • Cytokine-inducible Src homology 2 domain protein (CISH) is involved in immune regulation.

Purpose of the Study:

  • To examine the association between the CISH rs414171 single nucleotide polymorphism (SNP) and chronic hepatitis B (CHB) susceptibility.
  • Investigate the potential role of CISH genetic variations in HBV infection risk.

Main Methods:

  • A case-control study was conducted with 233 CHB patients and 148 healthy controls from the Chinese Han population.
  • Genotyping of the CISH rs414171 SNP was performed using Sequenom MassArray-IPLEX.
  • Allele and genotype frequencies were compared between cases and controls.

Main Results:

  • No statistically significant difference was observed in the allele or genotype frequencies of the CISH rs414171 SNP between CHB patients and healthy controls (P > 0.05).
  • The CISH rs414171 polymorphism does not appear to be a risk factor for chronic hepatitis B in this cohort.

Conclusions:

  • The CISH rs414171 SNP is not significantly associated with susceptibility to chronic hepatitis B in the Chinese Han population.
  • Further research may explore other genetic variations or environmental factors influencing CHB risk.
Abstract

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