Bioactive sesquiterpene polyol esters from the leaves of Tripterygium wilfordii

Tripterygium wilfordii, a member of Celastraceae family, has been used as a traditional plant insecticide and a medicinal plant. Phytochemical investigation of the leaves of T. wilfordii has resulted in the isolation of eight sesquiterpene polyol esters triptersinines M-T (1-8) and one sesquiterpene pyridine alkaloid (9). The structures of the compounds were elucidated on the basis of spectroscopic data analyses, including UV, IR, MS, and NMR experiments. The inhibitory effects on nitric oxide production in LPS-induced macrophages of 1-9 were also evaluated.