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Detection of Neuritic Plaques in Alzheimer's Disease Mouse Model
Published on: July 26, 2011
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Detection of Aβ plaques in mouse brain by using a disaggregation-induced fluorescence-enhancing probe
Yeon Ok Lee1, Jung-Won Shin, Chunsik Yi
1Department of Chemistry, Korea University, Seoul 136-701, Korea. jongskim@korea.ac.kr.
Chemical Communications (Cambridge, England)
|April 23, 2014
Abstract:
We herein report a fluorescence probe 1 capable of detecting water-soluble oligomeric Aβ aggregates and Aβ fibrils. Upon injection into Aβ42-challenged mouse brains, probe 1 shows increased fluorescence intensity, indicating its facile binding to extracellular Aβ fibrils in brain tissues.
