Full anterior segment biometry with extended imaging range spectral domain optical coherence tomography at 1340 nm

We demonstrate an extended-imaging-range anterior-segment optical coherence tomography (eAS-OCT) system for the biometric assessment of full AS in human eye. This newly developed eAS-OCT operating at 1340-nm wavelength band is simultaneously capable of an imaging speed of 120 kHz A-line scan rate, an axial resolution of 7.2 μm, and an extended imaging range of up to 16 mm in air. Imaging results from three healthy subjects and one subject with a narrow-angle demonstrate the instrument's utility. With this system, it can provide anatomical dimensions of AS, including central corneal thickness, anterior chamber width, anterior chamber depth, crystalline lens vault, crystalline lens thickness, angle opening distance (AOD500/AOD750), and the area described by the trabecular-iris space (TISA500/TISA750) at 500/750  μm. We also use eAS-OCT to image and quantify dynamic functional changes of the AS in response to a light stimulus that induces physiological pupillary changes as well as accommodative efforts that induce lens changes. The results show that the described eAS-OCT is able to provide full anatomical biometry for AS and is useful for the studies where the dynamic response of AS compartment to certain stimulus is required.