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Area of Science:

  • Neurogenetics
  • Brain Imaging Genetics

Background:

  • Regional brain structure indices like cortical thickness show variable heritability.
  • Heritability patterns change during development, supported by gene expression data.

Purpose of the Study:

  • Investigate genotype by age (G ×A) interactions in brain structure heritability during adulthood.
  • Explore changes in heritability across the lifespan in healthy aging.

Main Methods:

  • Analyzed genotype by age interactions in 902 subjects from the Genetics of Brain Structure (GOBS) study.
  • Utilized a novel jackknife-based method for analyzing stable cortical thickness clusters (JASC).

Main Results:

  • Additive genetic variance for cortical thickness remained constant throughout adulthood.
  • Found evidence of incomplete pleiotropy across age in paralimbic and parieto-temporal cortical thickness.

Conclusions:

  • Different genetic factors contribute to cortical thickness heritability at different ages in specific brain regions.
  • Heritability of brain structure is dynamic throughout adulthood, not static.