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Related Experiment Videos

Temperature distribution and pH changes during hyperthermic regional isolation perfusion.

J van der Zee1, M P Broekmeyer-Reurink, A P van den Berg

  • 1Department of Hyperthermia, Dr. Daniel den Hoed Cancer Center, Rotterdam, The Netherlands.

European Journal of Cancer & Clinical Oncology
|August 1, 1989
PubMed
Summary
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Hyperthermic perfusion effectively reduced bulky leg tumors in three patients. Pre-treatment tumor pH drop correlated with significant tumor regression and minimal toxicity, indicating a promising palliative treatment.

Area of Science:

  • Oncology
  • Medical Physics
  • Biochemistry

Background:

  • Bulky tumors in the leg present a palliative treatment challenge.
  • Hyperthermia is a potential therapeutic modality for cancer treatment.
  • Understanding tissue microenvironment changes during hyperthermia is crucial.

Purpose of the Study:

  • To evaluate hyperthermic perfusion as a palliative treatment for bulky leg tumors.
  • To monitor temperature and pH changes in tumor and normal tissues during treatment.
  • To assess the efficacy and toxicity of hyperthermic perfusion.

Main Methods:

  • Three patients with bulky leg tumors received hyperthermic perfusion (2 hours at 41.9-42.7°C).
  • Temperature and pH were continuously monitored in tumor and subcutaneous tissues.

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  • Tumor regression and toxicity were assessed post-treatment.

    • Main Results:

    • Temperature distribution within the tumor was heterogeneous.
    • Tumor pH significantly decreased from 7.11 to 5.94 before hyperthermia initiation.
    • Subcutaneous pH showed a minimal decrease of 0.29 units.
    • All patients experienced considerable tumor regression with no severe toxicity.

    Conclusions:

    • Hyperthermic perfusion is an effective debulking treatment for bulky leg tumors.
    • The significant pre-hyperthermia drop in tumor pH may enhance treatment effectiveness.
    • This approach shows potential as a palliative treatment option with good tolerability.