Related Experiment Videos
Effects of THA on ionic currents in myelinated axons of Xenopus laevis
F Elinder1, A K Mohammed, B Winblad
1Nobel Institute for Neurophysiology, Karolinska Institutet, Stockholm, Sweden.
European Journal of Pharmacology
|May 30, 1989
Abstract:
In voltage-clamp experiments with the myelinated nerve fibre of Xenopus laevis, 9-amino-1,2,3,4-tetrahydroacridine (THA) decreased both Na+ and K+ currents and shifted the steady state inactivation potential curve in a negative direction. The effects may be described as (a) a decrease of the permeability constant PNa, (b) a modified potential dependence of the inactivating system and (c) a decrease of PK. The Na+ system was affected more than the K+ system.