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Updated: May 1, 2026
Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
Published on: January 7, 2019
Oncolytic viruses targeting tumor stem cells
E Antonio Chiocca1, Donald Blair2, R Allan Mufson3
1Authors' Affiliations: Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA and.
Abstract:
A workshop "Targeting Oncolytic Viruses to Tumor Stem Cells," organized by the Division of Cancer Biology, NCI, NIH, was held on September 6, 2013 in Rockville, MD. Seventeen invited experts presented an overview of their current research in this area and discussed the state of current research on the use of oncolytic viruses targeted to stem cells as a potential cancer therapy. The goal was to evaluate the evidence that this approach might increase the efficacy of oncolytic virus therapy and to identify gaps in knowledge that have retarded progress in this area.
Insights
Experts explored using oncolytic viruses to target tumor stem cells for cancer therapy. The workshop evaluated evidence and identified knowledge gaps for this promising approach.
Area of Science:
- Oncology
- Virology
- Cancer Stem Cell Biology
Background:
- The workshop focused on the potential of oncolytic viruses to target cancer stem cells.
- This approach aims to enhance the efficacy of oncolytic virus therapy for cancer treatment.
Framework:
- Discussion centered on the current state of research for oncolytic viruses targeting stem cells.
- The goal was to assess evidence supporting this therapeutic strategy.
Implementation:
- Seventeen invited experts presented their research findings.
- The event facilitated discussion on the challenges and progress in the field.
Implications:
- Identified critical knowledge gaps hindering the advancement of this cancer therapy.
- Aimed to guide future research directions for more effective oncolytic virotherapy.
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