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Updated: May 1, 2026

Mapping Dysfunctional Protein-Protein Interactions in Disease
Published on: October 24, 2025
Alzheimer disease: An interactome of many diseases
Balaji S Rao1, Krishna Kant Gupta1, Pujitha Karanam1
1Department of Bioinformatics, NTHRYS Biotech Labs, Hyderabad, Andhra Pradesh, India.
Abstract:
Alzheimer Disease (AD) is an outcome as well as source of many diseases. Alzheimer is linked with many other diseases like Diabetes type 2, cholesterolemia, hypertension and many more. But how each of these diseases affecting other is still unknown to scientific community. Signaling Pathways of one disease is interlinked with other disease. But to what extent healthy brain is affected when any signaling in human body is disturbed is the question that matters. There is a need of Pathway analysis, Protein-Protein interaction (PPI) and the conserved interactome study in AD and linked diseases. It will be helpful in finding the potent drug or vaccine target in conscious manner. In the present research the Protein-Protein interaction of all the proteins involved in Alzheimer Disease is analyzed using ViSANT and osprey tools and pathway analysis further reveals the significant genes/proteins linking AD with other diseases.
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