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Related Concept Videos

Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

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A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
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Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...
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Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...
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An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
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Vasogenic edema is a major form of cerebral edema characterized by abnormal accumulation of fluid in the brain’s extracellular space due to disruption of the blood–brain barrier (BBB). The BBB is a specialized structure composed of endothelial cells connected by tight junctions, supported by astrocytic endfeet and a basement membrane. Under normal conditions, it tightly regulates the movement of ions, proteins, and solutes between the bloodstream and brain parenchyma. When this...
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Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum...
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Multiple cerebral infarctions with severe multi-organ dysfunction following multiple wasp stings.

Mushtaq Wani1, Sheikh Saleem1, Sawan Verma1

  • 1Department of Neurology, Sher-i-Kashmir Institute of Medical Sciences, Soura, Srinagar, Jammu and Kashmir, India.

Annals of Indian Academy of Neurology
|April 23, 2014
PubMed
Summary

Multiple wasp stings can cause severe multi-organ dysfunction, including stroke. This case highlights the critical systemic effects of insect stings beyond local reactions, emphasizing the need for prompt medical evaluation.

Keywords:
Disseminated Intravascular Coagulationstrokewasp sting

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Area of Science:

  • Toxicology
  • Neurology
  • Emergency Medicine

Background:

  • Wasp and bee stings are frequent global occurrences.
  • Most stings result in localized, self-limiting reactions.
  • Severe systemic effects, though rare, can be life-threatening.

Observation:

  • A 40-year-old male presented with stroke and right hemiparesis.
  • The patient experienced severe multi-organ dysfunction.
  • These severe symptoms were directly attributed to multiple wasp stings.

Findings:

  • Multiple insect stings can trigger a cascade of systemic complications.
  • Stroke and multi-organ failure are potential, albeit rare, outcomes of severe envenomation.
  • This case underscores the significant neurotoxic and systemic impact of wasp venom.

Implications:

  • Clinicians should consider severe systemic toxicity in patients with multiple insect stings, even without a history of allergy.
  • Prompt recognition and management of systemic effects are crucial for improving patient outcomes.
  • Further research into the mechanisms of severe systemic reactions to insect stings is warranted.