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Updated: May 1, 2026
Visual Detection of Multiple Nucleic Acids in a Capillary Array
Published on: November 15, 2017
Tandem array of nanoelectronic readers embedded coplanar to a fluidic nanochannel for correlated single biopolymer
Leonardo Lesser-Rojas1, K K Sriram1, Kuo-Tang Liao2
1Nano Science and Technology Program, Taiwan International Graduate Program, Academia Sinica, Taipei 11529, Taiwan ; Department of Engineering and System Science, National Tsing Hua University, Hsinchu 30013, Taiwan ; Institute of Physics, Academia Sinica, Taipei 11529, Taiwan.
Abstract:
We have developed a two-step electron-beam lithography process to fabricate a tandem array of three pairs of tip-like gold nanoelectronic detectors with electrode gap size as small as 9 nm, embedded in a coplanar fashion to 60 nm deep, 100 nm wide, and up to 150 μm long nanochannels coupled to a world-micro-nanofluidic interface for easy sample introduction. Experimental tests with a sealed device using DNA-protein complexes demonstrate the coplanarity of the nanoelectrodes to the nanochannel surface. Further, this device could improve transverse current detection by correlated time-of-flight measurements of translocating samples, and serve as an autocalibrated velocimeter and nanoscale tandem Coulter counters for single molecule analysis of heterogeneous samples.
