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Microfluidic Chips Controlled with Elastomeric Microvalve Arrays

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Published on: October 1, 2007

Euler force actuation mechanism for siphon valving in compact disk-like microfluidic chips.

Yongbo Deng¹, Jianhua Fan¹, Song Zhou¹

¹State Key Laboratory of Applied Optics, Changchun Institute of Optics, Fine Mechanics and Physics (CIOMP), Chinese Academy of Sciences, Changchun China, 130033.

Biomicrofluidics

|April 23, 2014

Summary

This study introduces a new microfluidic siphon valve actuated by Euler force, eliminating the need for external manipulation or complex chambers. This novel mechanism enables efficient whole blood separation and plasma extraction on compact disk-like chips.

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Area of Science:

Microfluidics
Biotechnology
Mechanical Engineering

Background:

Traditional microfluidic siphon valves often rely on capillary forces or external manipulation.
Existing methods can be limited by surface properties and require complex integrated systems like pneumatic pumps.

Purpose of the Study:

To present a novel actuation mechanism for siphon valving in microfluidic devices.
To demonstrate the use of Euler force for actuating siphon valves on compact disk (CD)-like platforms.
To validate the mechanism through numerical simulations and experimental implementation.

Main Methods:

Utilizing Euler force generated during the acceleration of a CD-like microfluidic chip.
Employing a phase-field based mathematical model for numerical simulation of fluid flow.
Manufacturing polymethylmethacrylate (PMMA)-based microfluidic chips using CO2 laser engraving.
Conducting experiments for whole blood separation and plasma extraction.

Main Results:

Euler force, dominant at initial acceleration, effectively fills and actuates the siphon valve.
Numerical simulations confirmed the Euler force actuation mechanism.
Experimental validation on PMMA microfluidic chips demonstrated successful siphon valving.
Achieved whole blood separation and plasma extraction using the novel actuation.

Conclusions:

The Euler force actuation mechanism provides a self-contained and efficient method for microfluidic siphon valving.
This approach avoids the limitations of hydrophilic capillary filling and complex pneumatic systems.
The developed technology offers a simplified and highly integrated solution for lab-on-a-chip applications.