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Interactions between intercellular adhesion molecule-5 positive elements and their surroundings in the rodent visual

Emily A Kelly1, Marie-Ève Tremblay1, Carl G Gahmberg2

  • 1Neurobiology & Anatomy; University of Rochester; Rochester, NY USA.

Communicative & Integrative Biology
|April 23, 2014
PubMed
Summary

Intercellular adhesion molecule 5 (ICAM-5) localization shifts during dendritic maturation, regulated by matrix metalloproteinase-9 (MMP-9). This cleavage impacts downstream signaling and neurotransmission in the developing brain.

Keywords:
ICAM-5Telencephalinelectron microscopymouseultrastructuralvisual cortex

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Area of Science:

  • Neuroscience
  • Cell Biology
  • Developmental Biology

Background:

  • Telencephalon-associated intercellular adhesion molecule 5 (ICAM-5) is crucial for dendritic maturation in the developing brain.
  • Extracellular proteases, specifically matrix metalloproteinase-9 (MMP-9), regulate ICAM-5 cleavage and downstream signaling.

Purpose of the Study:

  • To investigate the relationship between ICAM-5 and its neighboring structures.
  • To explore MMP-regulated ICAM-5 signaling pathways.

Main Methods:

  • Transmission electron microscopy was used to observe ICAM-5 localization.
  • Immunohistochemistry was employed to track ICAM-5 immuno-reactivity in wild-type and MMP-9 knockout mice.

Main Results:

  • ICAM-5 shifts from dendritic protrusions to shafts during maturation (P14 to P28 in mouse visual cortex).
  • This ICAM-5 shift is dependent on MMP-9 activity.
  • Cleaved ICAM-5 (sICAM-5) interacts with neighboring structures, influencing neurotransmission.

Conclusions:

  • MMP-9-mediated cleavage of ICAM-5 is a key regulator of its localization during dendritic maturation.
  • ICAM-5 signaling, influenced by MMP-9, plays a role in synaptic plasticity and neurotransmission.