Menstrual-like vaginal bleeding in prepubertal girls: an unexplained condition

Area of Science:

• Pediatric Gynecology
• Reproductive Endocrinology

Background:

• Unexplained cyclic vaginal bleeding is a rare occurrence in prepubertal girls.
• Existing literature consists of small case series (4-11 cases).

Purpose of the Study:

• To describe nine cases of prepubertal girls with unexplained cyclic vaginal bleeding.
• To contribute to the limited existing literature on this rare condition.

Main Methods:

• Retrospective case series.
• Inclusion of girls with cyclic vaginal bleeding.
• Exclusion of uterine and vaginal anomalies via gynecological, hormonal, and echographic examinations.

Main Results:

• Nine prepubertal girls presented with cyclic vaginal bleeding.
• No uterine or vaginal abnormalities were found in any of the cases.
• Hormonal and echographic examinations revealed no abnormalities.

Conclusions:

• Unexplained cyclic vaginal bleeding can occur in prepubertal girls without identifiable abnormalities.
• Further research is needed to elucidate the pathophysiology and management of this rare condition.