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Related Concept Videos

Menopause01:28

Menopause

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Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
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Hormonal Regulation of the Menstrual Cycle01:22

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The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
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Hormonal Regulation01:33

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The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
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Hormonal Regulation01:40

Hormonal Regulation

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Hormones regulate a significant portion of digestion through activation of the neuroendocrine system. The neuroendocrine system of digestion contains many different hormones all with multiple functions that are both, directly and indirectly, involved in digestion.
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Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Cancer Prevention02:59

Cancer Prevention

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Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
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Soy consumption during menopause.

S Bolca1, M Bracke2, H Depypere3

  • 1Laboratory for Bioinformatics and Computational Genomics (Biobix), Faculty of Bioscience Engineering, Ghent University, Coupure links 653, B-9000 Ghent, Belgium.

Facts, Views & Vision in Obgyn
|April 23, 2014
PubMed
Summary
This summary is machine-generated.

Soy phytoestrogens may offer partial estrogen receptor beta (ERβ) agonistic effects in breast tissue, potentially influencing menopausal symptoms and breast cancer risk. Further research is ongoing to understand their full impact.

Keywords:
Bone resorptionestrogensisoflavoneslipid profilemenopausephytoestrogenssoy

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Area of Science:

  • Endocrinology
  • Nutritional Science
  • Oncology

Background:

  • Menopause significantly impacts women's health, with phytoestrogens showing inconsistent effects on symptoms.
  • Individual differences in isoflavone metabolism, particularly equol production, contribute to varied treatment outcomes.
  • Soy phytoestrogens are investigated for their potential role in reducing breast cancer incidence.

Purpose of the Study:

  • To evaluate the estrogenic potential of soy phytoestrogens in human breast tissue.
  • To investigate the effects of soy isoflavones on bone turnover markers during menopause.

Main Methods:

  • Measured isoflavone-derived 17β-estradiol (E2) equivalents in human breast adipose and glandular tissue.
  • Analyzed the ratio of E2α and E2β equivalents to endogenous E2 concentrations.
  • Conducted randomized controlled trials on menopausal women measuring bone turnover markers.

Main Results:

  • Soy isoflavones' derived E2β-equivalents significantly exceeded endogenous E2 concentrations in breast tissue, suggesting partial ERβ agonistic effects.
  • Soy isoflavone supplements moderately decreased bone resorption markers (urinary deoxypyridinoline) but did not affect bone formation markers.

Conclusions:

  • Dietary soy phytoestrogens may exert partial ERβ agonistic effects in human breast tissue.
  • Soy isoflavones show a moderate benefit in reducing bone resorption during menopause.
  • Further research is needed to fully elucidate the mechanisms and clinical implications of soy phytoestrogens.