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Photodynamic therapy in gynecologic malignancies
S B Lele1, M S Piver, T S Mang
1Department of Gynecologic Oncology, Roswell Park Memorial Institute, Buffalo, New York 14263.
Gynecologic Oncology
|September 1, 1989
Summary
Photodynamic therapy using Photofrin II and an argon dye laser showed promise for recurrent gynecologic cancers. Some patients with skin lesions and cervical/vaginal recurrences experienced significant tumor response.
Area of Science:
- Oncology
- Photomedicine
Background:
- Recurrent gynecologic malignancies pose significant treatment challenges.
- Photodynamic therapy (PDT) offers a potential therapeutic modality.
Purpose of the Study:
- To evaluate the efficacy of photodynamic therapy (PDT) using Photofrin II and an argon dye laser in patients with recurrent gynecologic malignancies.
Main Methods:
- Twenty-one patients with recurrent gynecologic malignancies were enrolled.
- Treatment involved photodynamic therapy with Photofrin II and argon dye laser.
- Patients with cutaneous lesions received palliative treatment.
Main Results:
- Seven of twenty-one patients with cutaneous lesions achieved a complete response.
- Four of eleven patients with cervical and vaginal recurrences showed an objective response.
- Two patients with a complete response remained disease-free at 28 and 36 months.
Conclusions:
- Photodynamic therapy with Photofrin II and argon dye laser demonstrates potential as a palliative and therapeutic option for recurrent gynecologic malignancies.
- Further investigation is warranted to optimize PDT protocols for gynecologic cancer recurrence.