Acute lymphoblastic leukaemia therapy in Poland. A report from the Polish Children's Leukaemia/Lymphoma Study Group

Area of Science:

• Pediatric Oncology
• Hematology
• Clinical Research

Background:

• Acute lymphoblastic leukemia (ALL) is a significant health concern in pediatric populations.
• Effective treatment protocols are crucial for improving survival rates in children with ALL.
• The BFM Protocol has been a widely used treatment regimen for childhood ALL.

Purpose of the Study:

• To present the treatment outcomes for a large cohort of children diagnosed with ALL in Poland.
• To specifically analyze the results of patients treated between 1981-1985 using the BFM Protocol.
• To determine the 6-year continuous complete remission (CCR) probability for this patient group.

Main Methods:

• Retrospective analysis of treatment data from 1304 children with ALL.
• Detailed examination of a subgroup of 524 patients treated from 1981 to 1985.
• Application of the Berlin-Frankfurt-Münster (BFM) Protocol for treatment.

Main Results:

• The study included 1304 children with ALL, with 524 undergoing detailed analysis.
• Patients were treated according to the BFM Protocol during the 1981-1985 period.
• The 6-year continuous complete remission (CCR) probability was found to be 0.56.

Conclusions:

• The BFM Protocol demonstrated a 6-year CCR probability of 0.56 in Polish children with ALL treated between 1981-1985.
• These findings contribute to understanding the long-term efficacy of this protocol in a specific national context.
• Further research may explore factors influencing remission rates and long-term survival in pediatric ALL.