Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Acute lymphatic leukemia with pre-B-cell characteristics].

A Sauerbrey1, R Häfer, F Zintl

  • 1Universitäts-Kinderklinik und Poliklinik Jussuf Ibrahim Jena.

Folia Haematologica (Leipzig, Germany : 1928)
|January 1, 1989
PubMed
Summary

This study analyzed immunological subtypes of acute lymphatic leukaemia (ALL) in 54 patients. T-cell ALL (T-ALL) presented a worse prognosis compared to other subtypes like pre-B-ALL.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prevalence of antibodies against influenza A and B viruses in children in Germany, 2008 to 2010.

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin·2014
Same author

Response of children with stage IV soft tissue sarcoma to topotecan and carboplatin: a phase II window trial of the cooperative soft tissue sarcoma group.

Klinische Padiatrie·2013
Same author

Prevalence of antibodies against hepatitis A virus among children and adolescents in Germany.

Medical microbiology and immunology·2013
Same author

Multiple viral infections after haploidentical hematopoietic stem cell transplantation in a child with acute lymphoblastic leukemia.

Transplant infectious disease : an official journal of the Transplantation Society·2012
Same author

[GATA1-mutation associated leukemia in children with trisomy 21 mosaic].

Klinische Padiatrie·2012
Same author

Prognostic-significance of protein-kinase-C in newly-diagnosed childhood acute lymphoblastic-leukemia.

International journal of oncology·2011

Area of Science:

  • Hematology
  • Immunology
  • Oncology

Context:

  • Acute Lymphatic Leukaemia (ALL) is a significant hematologic malignancy.
  • Understanding ALL subtypes is crucial for targeted treatment strategies.
  • Immunophenotyping plays a key role in classifying ALL.

Purpose:

  • To determine the frequency of pre-B acute lymphatic leukaemia (pre-B-ALL) among other immunological subtypes.
  • To compare clinical parameters across different ALL subtypes.
  • To assess the prognostic significance of immunological subtypes in ALL.

Summary:

  • 54 patients with ALL were classified into five immunological subtypes: pre-B-ALL (16.6%), O-ALL (37.1%), C-ALL (27.9%), T-ALL (16.6%), and B-ALL (1.8%).
  • Immunophenotyping markers included cytoplasmic IgM, sheep erythrocyte rosettes, T-cell specific antigen, C-ALL antigen, and surface immunoglobulin.
  • Clinical parameters such as age, leukocyte count, mediastinal tumors, and CNS involvement were analyzed across subtypes.

Impact:

  • Identified T-cell ALL (T-ALL) as having a distinctly worse prognosis.
  • Demonstrated no significant clinical differences between O-ALL, pre-B-ALL, and C-ALL.
  • Highlights the importance of immunological subtyping for predicting ALL patient outcomes.

Related Experiment Videos