[Technological parameter optimization method for washing of coarse bear gall powder extracts based on NIR...

Area of Science:

• Analytical Chemistry
• Process Chemistry

Context:

• Optimizing the extraction of active compounds from natural products is crucial for pharmaceutical applications.
• The washing process of coarse bear gall powder extracts requires precise control of ethyl acetate levels to maximize yield and purity.

Purpose:

• To develop a flexible and accurate method for optimizing the washing process of coarse bear gall powder extracts.
• To utilize Near-Infrared (NIR) spectroscopy combined with chemometrics for predicting product yield and purity.

Summary:

• Forty batches of coarse bear gall powder extracts were analyzed using NIR spectra.
• Principal Component Analysis (PCA) was employed, and the first 8 principal components were used with ethyl acetate amount to build predictive models for yield and purity.
• Models were validated using 30 calibration batches and 10 validation batches, showing high correlation coefficients and low root-mean-square errors for both yield and purity prediction.

Impact:

• Demonstrates the effectiveness of NIR spectra and chemometrics in predicting and optimizing natural product extraction processes.
• Enables flexible adjustment of ethyl acetate quantity based on raw material properties, leading to enhanced yield and purity of bear gall powder extracts.
• Provides a foundation for real-time process monitoring and control in the extraction of valuable compounds from natural sources.