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Synthesis and biological activity of substance P analogues
I Haro1, J L Torres, G Valencia
1Laboratory of Peptides, Centre for Research and Development (C.S.I.C.), Barcelona, Spain.
International Journal of Peptide and Protein Research
|May 1, 1989
Abstract:
The synthesis of the hexapeptide [Glu6]SP6-11 and its glycosylated analogue at the Glu6 gamma-carboxyl position by solution procedures according to several strategies is discussed. The biological activity of SP, [Glu6]SP6-11 (VI) and [Glu(beta-D-Glcp)6]SP6-11 (VIII) have been determined and compared to SP by the GPI and RVD assays. The introduction of a beta-D-glucopyranosyl moiety at the sixth position of the [Glu6]SP6-11 did not affect to a great extent the in vitro activity pattern of the parent hexapeptide.