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Bronchopulmonary dysplasia: NHLBI Workshop on the Primary Prevention of Chronic Lung Diseases
Cindy T McEvoy1, Lucky Jain, Barbara Schmidt
11 Department of Pediatrics, Oregon Health and Science University, Portland, Oregon.
Insights
Preventing bronchopulmonary dysplasia (BPD), a common complication in preterm infants, remains challenging. This report outlines barriers to BPD prevention research and suggests priorities for improving infant lung health.
Area of Science:
- Neonatal Medicine
- Pediatric Pulmonology
- Developmental Biology
Background:
- Bronchopulmonary dysplasia (BPD) is the most frequent complication following extreme preterm birth.
- BPD leads to abnormal lung development and lasting cardiopulmonary issues in affected infants.
- Primary prevention of BPD has not yet been achieved despite extensive research efforts.
Purpose of the Study:
- To identify existing barriers hindering primary prevention studies for BPD.
- To explore the causal pathways involved in BPD pathogenesis.
- To highlight research avenues for understanding lung development and BPD.
Main Methods:
- Workshop report synthesizing current knowledge and expert opinions.
- Analysis of barriers in conducting primary BPD prevention research.
- Review of BPD pathogenesis and potential therapeutic targets.
Main Results:
- Identified key obstacles to conducting primary BPD prevention studies.
- Outlined complex causal pathways contributing to BPD development.
- Highlighted the need for research into normal and aberrant lung development.
Conclusions:
- Emphasized the need to distinguish BPD endotypes for targeted therapies.
- Stressed the importance of identifying biomarkers for precise prevention strategies.
- Recommended research priorities to accelerate discovery and enhance preterm infant lung health.
Abstract:
Bronchopulmonary dysplasia (BPD) is the most common complication of extreme preterm birth. Infants who develop BPD manifest aberrant or arrested pulmonary development and can experience lifelong alterations in cardiopulmonary function. Despite decades of promising research, primary prevention of BPD has proven elusive. This workshop report identifies current barriers to the conduct of primary prevention studies for BPD and causal pathways implicated in BPD pathogenesis. Throughout, we highlight promising areas for research to improve understanding of normal and aberrant lung development, distinguish BPD endotypes, and ascertain biomarkers for more targeted therapeutic approaches to prevention. We conclude with research recommendations and priorities to accelerate discovery and promote lung health in infants born preterm.
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Assessment