Related Experiment Video
Updated: Apr 30, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Structure-based design and synthesis of bicyclic fused-pyridines as MEK inhibitors
Hejun Lu1, Wangyang Tu1, Hongbo Fei1
1Shanghai Hengrui Pharmaceutical Co., Ltd, 279 Wenjing Rd., Minhang District, Shanghai 200245, China.
Abstract:
The MAPK pathway is identified as one of the most important pathways involved in cell proliferation and differentiation. A key kinase in the pathway, the Mitogen-activated protein kinase kinase (MEK) is recognized as a promising target for antitumor drugs. Structure-based design and optimization of known MEK inhibitors resulted in identification of compound 10a as a potent non-ATP competitive MEK inhibitor in both in vitro and in vivo tests.
Related Concept Videos
Diels–Alder Reaction Forming Bridged Bicyclic Products: Stereochemistry
Basicity of Heterocyclic Aromatic Amines
Structure-Activity Relationships and Drug Design
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence...

