Related Experiment Video
Updated: Apr 30, 2026
11:21
Bioinformatics Resources for the Study of Glycan-Mediated Protein Interactions
Published on: January 20, 2022
3.3K
Community-based network study of protein-carbohydrate interactions in plant lectins using glycan array data
Adeel Malik1, Juyong Lee1, Jooyoung Lee1
1Center for In Silico Protein Science, School of Computational Sciences, Korea Institute for Advanced Study, Seoul, Korea.
Plos One
|April 24, 2014
Summary
This study introduces a network analysis method to understand lectin-glycan interactions. It reveals key lectin hubs and functional groups, aiding glycobiology research.
Area of Science:
- Glycobiology
- Systems Biology
- Bioinformatics
Background:
- Lectins are crucial for biological processes like immune response and cell adhesion.
- Glycan microarrays offer insights into protein-glycan interactions at an omics scale.
- Systematic analysis tools for glycan microarray data are currently lacking.
Purpose of the Study:
- To develop a systematic analysis tool for lectin-glycan interaction data.
- To group lectins and their carbohydrate-binding specificities using network analysis.
- To identify key lectins (hubs) and functional groups within lectin-carbohydrate networks.
Main Methods:
- Construction of a lectin-carbohydrate interaction network.
- Application of community-based analysis to the network.
- Identification of network hubs and statistically significant functional groups.
Main Results:
- The lectin-carbohydrate network comprises 1119 nodes and 16769 edges.
- Three lectins were identified as significant hubs with high connectivity.
- Community analysis revealed statistically significant functional groups within the network.
Conclusions:
- Community-based network analysis provides an effective method for understanding lectin-glycan interactions.
- This approach simplifies the interpretation of complex glycan microarray data.
- The identified hubs and functional groups offer insights into lectin roles in biological systems.
Related Concept Videos
02:26Protein Networks
3.7K
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
3.7K
02:04Protein-protein Interfaces
12.5K
Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
12.5K