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Early prediction of complex midgut volvulus in neonates and infants
Ilias Kanellos-Becker1, Robert Bergholz, Konrad Reinshagen
1Department of Pediatric Surgery, University Hospital Hamburg-Eppendorf and Altona Children's Hospital, Martinistrasse 54, 20246, Hamburg, Germany.
Insights
Early detection of complex midgut volvulus in infants is crucial. A simple score combining base excess and preterm birth can identify high-risk infants, potentially reducing mortality and morbidity.
Area of Science:
- Pediatric Surgery
- Neonatal Care
- Gastrointestinal Motility Disorders
Background:
- Midgut volvulus in infants under one year has a poor prognosis, often diagnosed late after intestinal infarction.
- Timely diagnosis is challenging due to non-specific clinical and radiological findings.
Purpose of the Study:
- To identify predictive factors for early diagnosis of complex midgut volvulus in infants.
- To develop a scoring system to differentiate between simple and complex midgut volvulus.
Main Methods:
- Retrospective analysis of 37 infants under one year treated for midgut volvulus (2002-2011).
- Evaluation of medical history, symptoms, laboratory, and radiological findings.
- Classification Tree (CART) analysis to identify key discriminators.
Main Results:
- 16% mortality and 43% complication rate observed.
- Base excess < -1.70 and preterm birth (<36 weeks) were significant predictors.
- A score based on these factors achieved 100% sensitivity and 85.7% specificity for complex midgut volvulus.
Conclusions:
- Midgut volvulus significantly impacts infant morbidity and mortality.
- A novel scoring system effectively identifies infants at high risk for complex midgut volvulus.
- This score can aid in earlier diagnosis and potentially reduce adverse outcomes.
Introduction:
Prognosis of midgut volvulus in neonates and infants younger than 1 year remains poor, as diagnostic findings may not be apparent until gut infarction had occurred. To characterize factors that help to predict complex midgut volvulus early was aim of this study.
Methods:
Institutionally approved retrospective analysis of all children younger than 1 year treated for midgut volvulus at the author's center from January 2002 to December 2011. Medical history, symptoms, laboratory and radiologic findings as well as sequelae of midgut volvulus were evaluated.
Results:
In 10 years, 37 children fulfilled the inclusion criteria. Of these, 43% developed complications, and mortality rate was 16%. In 30% of the patients, the only clinical sign was a sudden worsening of the general condition and abdominal distension (complex 19% vs. simple 38%). In one child with simple midgut volvulus, all clinical, laboratory and radiologic signs were negative. CART analysis identified a base excess below -1.70 and preterm birth (<36 weeks) as the best discriminators of complex and simple midgut volvulus. A score >1pt (comprised of these two factors) was found in all children with complex and in 14% of simple midgut volvulus (p < 0.001). A positive score (>1pt) offers a sensitivity of 100% (81.7-100%), specificity of 85.7% (71.8-85.7%), a PPV of 84.2% (68.8-84.2%) and NPV 100% (83.8-100%).
Discussion:
The study shows that midgut volvulus has a substantial morbidity and mortality. Unfortunately, not all affected children get picked up by history, laboratory and imaging. However, the proposed score helps to identify subject with increased risk of complications. It has the potential to facilitate and accelerate diagnosis of complex midgut volvulus; ultimately, it might help to reduce morbidity and mortality.
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