Transition metal-catalyzed C-C bond activation of four-membered cyclic ketones

With the advent of new synthetic methodologies, carbon-carbon bond (C-C) activation strategies have uncovered not only new fundamental reactivity but also the potential for use as a highly efficient synthetic protocol. This chapter specifically discusses the use of four-membered ketone-based starting materials for C-C activation initiated transformations using a variety of transition metals. The two major modes of activation, oxidative addition and β-C elimination, are presented as each pathway shows different mechanistic details and the ability to effect several types of reactions. Applications to the synthesis of complex molecules are presented and perspectives on future applications are considered.