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Related Experiment Video

Updated: Apr 30, 2026

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4

Published on: December 31, 2013

TRPV6 channels.

Claudia Fecher-Trost¹, Petra Weissgerber, Ulrich Wissenbach

¹Institut für Experimentelle und Klinische Pharmakologie und Toxikologie, Universität des Saarlandes, 66421, Homburg, Germany.

Handbook of Experimental Pharmacology

|April 24, 2014

Summary

This summary is machine-generated.

TRPV6 channels are unique, highly Ca2+-selective, and their gene expression is upregulated in cancers. This channel is essential for male fertility and has unique translation initiation and human-specific polymorphisms.

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Published on: January 7, 2019

Area of Science:

Molecular Biology
Genetics
Physiology

Background:

TRPV6 (Transient Receptor Potential Vanilloid 6) is a highly calcium-selective ion channel.
It belongs to the TRP superfamily and exhibits unique characteristics compared to other TRP channels.
TRPV6 plays crucial roles in calcium homeostasis and has implications in various physiological and pathological processes.

Purpose of the Study:

To highlight the unique features of TRPV6, including its Ca2+ selectivity, unusual translation initiation, and human-specific genetic variations.
To discuss the role of TRPV6 in human health and disease, particularly in cancer and male fertility.
To provide a comprehensive overview of the current understanding of TRPV6.

Main Methods:

Literature review of existing studies on TRPV6.
Analysis of genetic polymorphisms and their evolutionary significance.
Examination of TRPV6 gene expression patterns in various human tissues and diseases.
Review of functional studies on TRPV6, including knockout mouse models.

Main Results:

TRPV6 is one of the only highly Ca2+-selective channels in the TRP superfamily.
TRPV6 translation initiates at a non-AUG codon (ACG), producing a full-length protein with an extended N-terminus.
A human-specific TRPV6 haplotype (derived) shows evidence of positive selection.
TRPV6 gene expression is upregulated in several human cancers, including prostate and breast cancer.
TRPV6 is essential for male fertility, as demonstrated by infertility in male mice lacking functional TRPV6 channels.

Conclusions:

TRPV6 possesses unique molecular and genetic features that distinguish it within the TRP channel family.
Its dysregulation in cancer and essential role in male fertility underscore its clinical significance.
Further research into TRPV6 is warranted to explore its therapeutic potential.