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Related Concept Videos

Thermosensation01:43

Thermosensation

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Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
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The trp operon in Escherichia coli exemplifies a repressible operon. It regulates the synthesis of tryptophan through repressor-mediated transcriptional control and attenuation. This dual regulatory mechanism ensures tryptophan biosynthesis occurs only when needed, conserving cellular resources.Structure of the trp OperonThe trp operon consists of five structural genes (trpE, trpD, trpC, trpB, and trpA) that encode enzymes for tryptophan biosynthesis. These genes are transcribed as a single...
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LTR retrotransposons are class I transposable elements with long terminal repeats flanking an internal coding region. These elements are less abundant in mammals compared to other class I transposable elements. About 8 percent of human genomic DNA comprises LTR retrotransposons. Some of the common examples of LTR retrotransposons are Ty elements in yeast and Copia elements in Drosophila.
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Related Experiment Video

Updated: Apr 30, 2026

A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice
08:35

A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice

Published on: March 17, 2015

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TRPM3.

Johannes Oberwinkler1, Stephan E Philipp

  • 1Institut für Physiologie und Pathophysiologie, Philipps-Universität Marburg, 35037, Marburg, Germany, johannes.oberwinkler@uni-marburg.de.

Handbook of Experimental Pharmacology
|April 24, 2014
PubMed
Summary
This summary is machine-generated.

The Trpm3 gene produces unique TRPM3 ion channels with diverse functions, including heat sensing and insulin modulation. Further research with new tools will reveal more about these complex channels.

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Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy
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Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy

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Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy
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Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy

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Area of Science:

  • Molecular Biology
  • Ion Channel Physiology
  • Gene Regulation

Background:

  • TRP channels are crucial for cellular functions.
  • TRPM3 channels exhibit unique characteristics compared to other TRP family members.
  • The Trpm3 gene locus is complex, involving alternative splicing and a co-transcribed microRNA (miR-204).

Purpose of the Study:

  • To summarize the unique features of TRPM3 channels.
  • To highlight the role of alternative splicing and miR-204 in TRPM3 functional complexity.
  • To review the progress in identifying TRPM3 channel functions and pharmacological tools.

Main Methods:

  • Analysis of alternative splicing in Trpm3 gene.
  • Investigating the function of miR-204 in Trpm3 locus regulation.
  • Utilizing pharmacological tools to study TRPM3 channel activity in various cell types.

Main Results:

  • Trpm3 gene generates numerous isoforms, with known functional consequences for selectivity and channel activity.
  • miR-204 regulates multiple genes, adding complexity to the Trpm3 locus.
  • Functional TRPM3 channels identified in nociceptive neurons, pancreatic beta cells, and vascular smooth muscle cells.
  • TRPM3 channels implicated in noxious heat sensing, insulin release modulation, and inflammatory cytokine secretion.

Conclusions:

  • TRPM3 channels possess unique properties and diverse functions.
  • Pharmacological and genetic tools are advancing the understanding of TRPM3 channels.
  • Future research is expected to uncover novel functions of TRPM3 channels in various tissues.