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Related Concept Videos

Thermosensation01:43

Thermosensation

29.7K
Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
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G-protein Coupled Receptors01:21

G-protein Coupled Receptors

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G-protein coupled receptors are ligand binding receptors that indirectly affect changes in the cell. The actual receptor is a single polypeptide that transverses the cell membrane seven times creating intracellular and extracellular loops. The extracellular loops create a ligand specific pocket which binds to neurotransmitters or hormones. The intracellular loops holds onto the G-protein.
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G-protein Coupled Receptors01:21

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G Protein-coupled Receptors01:15

G Protein-coupled Receptors

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G Protein-Coupled Receptors or GPCRs are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to sensory stimuli such as light, odors, hormones, cytokines, or neurotransmitters.
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...
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G Protein-coupled Receptors01:15

G Protein-coupled Receptors

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GPCR Desensitization01:12

GPCR Desensitization

6.1K
G protein-coupled receptor (GPCR) signaling plays a crucial role in cell functioning. GPCR desensitization is an equally essential process. It allows cells to respond to changing environments and regain sensitivity to new stimuli while preventing unnecessary stimulation when no longer needed. Prolonged exposure to stimuli leads to GPCR desensitization. It involves blocking the receptors from binding and activating additional G proteins. This inhibits activation of downstream effectors, thereby...
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Related Experiment Video

Updated: Apr 30, 2026

A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice
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A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice

Published on: March 17, 2015

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TRPM5.

Emily R Liman1

  • 1Section of Neurobiology, Department of Biological Sciences, University of Southern California, 3641 Watt Way, Los Angeles, CA, 90089, USA, liman@usc.edu.

Handbook of Experimental Pharmacology
|April 24, 2014
PubMed
Summary

Transient Receptor Potential Melastatin 5 (TRPM5) channels are crucial for taste and chemosensation. Recent research explores TRPM5

Area of Science:

  • Physiology
  • Molecular Biology
  • Neuroscience

Background:

  • Transient Receptor Potential Melastatin 5 (TRPM5) is a Ca(2+)-activated cation channel central to chemosensation.
  • It acts as the final component in signaling cascades initiated by G protein-coupled receptors for bitter, sweet, and umami tastes.
  • TRPM5 is also found in pancreatic islets, contributing to insulin secretion.

Purpose of the Study:

  • To review recent advancements in understanding TRPM5 channel activation mechanisms.
  • To discuss the regulation of TRPM5 by various factors including voltage, phosphoinositides, temperature, and pH.
  • To explore the distribution and functional roles of TRPM5 in both sensory and non-sensory systems.

Main Methods:

  • Literature review of recent research on TRPM5.

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Purification and Reconstitution of TRPV1 for Spectroscopic Analysis
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Purification and Reconstitution of TRPV1 for Spectroscopic Analysis

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Related Experiment Videos

Last Updated: Apr 30, 2026

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A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice

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Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4
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Purification and Reconstitution of TRPV1 for Spectroscopic Analysis

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  • Analysis of studies investigating TRPM5 activation and regulation.
  • Synthesis of data on TRPM5 distribution and physiological functions.

    • Main Results:

    • TRPM5 activation involves a signaling cascade including PLCβ2, PIP2 breakdown, and Ca(2+) release.
    • TRPM5 exhibits sensitivity to voltage, phosphoinositides, temperature, and pH.
    • The channel is expressed in diverse chemosensory cells throughout the digestive, respiratory, and olfactory systems, as well as in pancreatic islets.

    Conclusions:

    • TRPM5 plays a significant role in taste perception and chemosensation.
    • Its widespread distribution suggests broader physiological functions beyond taste, including metabolic regulation.
    • Further research into TRPM5 mechanisms and regulation is essential for understanding its full physiological impact.