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Related Concept Videos

Thermosensation01:43

Thermosensation

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Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
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The trp operon in Escherichia coli exemplifies a repressible operon. It regulates the synthesis of tryptophan through repressor-mediated transcriptional control and attenuation. This dual regulatory mechanism ensures tryptophan biosynthesis occurs only when needed, conserving cellular resources.Structure of the trp OperonThe trp operon consists of five structural genes (trpE, trpD, trpC, trpB, and trpA) that encode enzymes for tryptophan biosynthesis. These genes are transcribed as a single...
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Enzyme-linked receptors are proteins that act as both receptor and enzyme, activating multiple intracellular signals. This is a large group of receptors that include the receptor tyrosine kinase (RTK) family. Many growth factors and hormones bind to and activate the RTKs.
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GPCRs are primarily responsible for our sense of smell, taste, and vision.  The binding of a sensory stimulus activates GPCR to stimulate effector proteins, many of which are ion channels in the sensory organs. GPCRs modulate the opening and closing of the target ion channels either directly by binding them, or by releasing second messengers that activate these channels. As ions move across the membrane, the membrane potential is altered, which induces an appropriate response.
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Related Experiment Video

Updated: Apr 30, 2026

A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice
08:35

A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice

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TRPM8.

Laura Almaraz1, Jan-Albert Manenschijn, Elvira de la Peña

  • 1Instituto de Neurociencias de Alicante, Universidad Miguel Hernández-CSIC, Avenida S. Ramón y Cajal s.n., San Juan de Alicante, 03550, Spain.

Handbook of Experimental Pharmacology
|April 24, 2014
PubMed
Summary
This summary is machine-generated.

Transient receptor potential melastatin 8 (TRPM8) is a cold-activated ion channel crucial for temperature sensation. Research explores its properties and links to diseases like pain and cancer.

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Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy
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Related Experiment Videos

Last Updated: Apr 30, 2026

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Area of Science:

  • Neuroscience
  • Molecular Biology
  • Physiology

Background:

  • Transient receptor potential melastatin 8 (TRPM8) was initially identified in prostate tissue.
  • TRPM8 functions as a cold- and menthol-activated ion channel in peripheral sensory neurons.
  • It plays a vital role in detecting cold temperatures.

Purpose of the Study:

  • To review the molecular and biophysical properties of TRPM8.
  • To discuss the pharmacology and modulation of TRPM8 by signaling molecules.
  • To examine the physiological role and disease associations of TRPM8.

Main Methods:

  • Literature review of existing research on TRPM8.
  • Analysis of molecular and biophysical data.
  • Examination of pharmacological studies and signaling pathways.

Main Results:

  • TRPM8 exhibits distinct molecular and biophysical characteristics.
  • Its activity is modulated by various signaling molecules.
  • TRPM8 is implicated in cold sensation and various physiological processes.

Conclusions:

  • TRPM8 is a key player in cold detection and sensory neuron function.
  • Dysregulation of TRPM8 is linked to human diseases including pain, prostate cancer, dry eye, and metabolic disorders.