Serum gonadotropins in postmenopausal women after long-term verapamil treatment

The effect of long-term verapamil treatment on serum gonadotropin levels was studied in 13 postmenopausal women aged 48-73 years given verapamil 160-320 mg daily for 2-8 months. Serum luteinizing hormone and follicle stimulating hormone concentrations were unchanged during verapamil treatment [7.1 (5.8:11.0) and 24 (21:26) micrograms/L before and 8.8 (5.1:9.1) and 25 (19:31) micrograms/L following verapamil]. This suggests that chronic calcium influx inhibition has no major influence on the release of gonadotropins from pituitary cells.