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Related Concept Videos

Cancers Originate from Somatic Mutations in a Single Cell02:21

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Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
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Primary Orthotopic Glioma Xenografts Recapitulate Infiltrative Growth and Isocitrate Dehydrogenase I Mutation
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Triple primary origin tumor: a case report.

Yong-Su Jung1, Se-Hoon Kim1, Sung-Kon Ha1

  • 1Department of Neurosurgery, Ansan Hospital, Korea University School of Medicine, Ansan, Republic of Korea.

Korean Journal of Spine
|April 24, 2014
PubMed
Summary
This summary is machine-generated.

This case study highlights a rare instance of a triple primary origin tumor. Pathologic confirmation is crucial for accurate diagnosis and treatment, even with a history of other cancers.

Keywords:
Pathologic diagnosisPrimary spinal tumorSpinal metastasisTriple primary origin tumor

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Area of Science:

  • Oncology
  • Pathology

Background:

  • Extradural spinal tumors are more commonly metastatic than primary.
  • Patients with a history of cancer are often presumed to have metastatic spinal lesions.

Purpose of the Study:

  • To report a rare case of a triple primary origin tumor.
  • To emphasize the importance of pathological confirmation in spinal tumor diagnosis.

Main Methods:

  • A 57-year-old male patient with a history of colon and liver cancer presented with a spinal lesion.
  • Initial diagnosis was presumed metastatic disease.
  • Surgical intervention and subsequent pathological examination were performed.

Main Results:

  • The spinal lesion was pathologically confirmed as plasmacytoma, representing a third primary tumor.
  • The patient received chemotherapy post-surgery.

Conclusions:

  • Triple primary origin tumors are exceptionally rare.
  • Pathological confirmation is essential for appropriate treatment, even in patients with pre-existing malignancies.