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Advances in immune-modulating therapies to treat atherosclerotic cardiovascular diseases

Kuang-Yuh Chyu1, Prediman K Shah2

  • 1Oppenheimer Atherosclerosis Research Center, Division of Cardiology, Cedars-Sinai Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Therapeutic Advances in Vaccines
|April 24, 2014
PubMed

In addition to hypercholesterolemia, innate and adaptive immune mechanisms play a critical role in atherogenesis, thus making immune-modulation therapy a potentially attractive way of managing atherosclerotic cardiovascular disease. These immune-modulation strategies include both active and passive immunization and confer beneficial reduction in atherosclerosis. Preclinical studies have demonstrated promising results and we review current knowledge on the complex role of the immune system and the potential for immunization as an immune-modulation therapy for atherosclerosis.

Keywords:
atherosclerosisimmune responseimmunization

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