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Related Concept Videos

Psychosis and Antipsychotic Drugs: Overview01:28

Psychosis and Antipsychotic Drugs: Overview

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The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic...
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Antidepressant Drugs: MAOIs and Other Agents01:23

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Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
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Drug Therapy01:28

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The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
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Psychosis: Goals of Pharmacotherapy01:26

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Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
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Antipsychotic Drugs: Typical and Atypical Agents01:21

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Antipsychotic drugs are classified into first-generation (typical) drugs including phenothiazines; and second-generation (atypical) drugs. Chlorpromazine hydrochloride (Thorazine), a phenothiazine derivative, broadly impacts the central, autonomic, and endocrine systems. This drug, along with typical agents like haloperidol (Haldol), primarily works by antagonizing D2 receptors, thus reducing dopaminergic neurotransmission. However, typical antipsychotics can cause side effects such as sedation...
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Tricyclic Antidepressants (TCAs), including Desipramine (Norpramin), Imipramine (Tofranil), Clomipramine (Anafranil), and Amitriptyline (Elavil), inhibit serotonin and norepinephrine reuptake and also block other receptors. They are used for depression, pain conditions, and insomnia. Common adverse effects include anticholinergic effects, sedation, orthostatic hypotension, and weight gain. They have a narrow therapeutic window and so require plasma-level monitoring. Abrupt discontinuation can...
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Updated: Jan 3, 2026

Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model
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Psychotropics and sexual dysfunction.

Anthony J Bella1, Rany Shamloul2

  • 1Greta and John Hansen Chair in Men's Health Research, Division of Urology, Department of Surgery Associate Scientist, Neuroscience University of Ottawa, Canada.

Central European Journal of Urology
|April 24, 2014
PubMed
Summary
This summary is machine-generated.

Sexual dysfunction (SD) is a common side effect of antipsychotic medications, impacting patient compliance. More research is needed to understand the exact causes and mechanisms of drug-induced sexual dysfunction.

Keywords:
psychotropicssexual dysfunction

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Area of Science:

  • Psychiatry
  • Pharmacology
  • Sexual Medicine

Background:

  • Sexual dysfunction (SD) is a prevalent and bothersome adverse drug effect in patients treated with antipsychotics, frequently compromising treatment adherence.
  • The precise mechanisms underlying psychotropic-induced SD remain poorly understood.
  • Understanding SD in psychiatric patients requires differentiating drug effects from other factors.

Purpose of the Study:

  • To provide an updated analysis of sexual dysfunction associated with psychotropic drug use in psychiatric patients.
  • To review current evidence on the incidence and drug-relatedness of sexual dysfunction.
  • To highlight the need for further research into the mechanisms of psychotropic-induced sexual dysfunction.

Main Methods:

  • Systematic review of contemporary studies.
  • Analysis of evidence on drug-related versus drug-class specific effects.
  • Evaluation of factors influencing reported rates of sexual dysfunction.

Main Results:

  • Sexual dysfunction rates appear to be drug-related rather than specific to drug classes.
  • Reported rates of sexual dysfunction vary widely across studies.
  • Current understanding is limited by challenges in differentiating drug-induced effects from other variables.

Conclusions:

  • Rigorous basic and clinical research is essential to elucidate the exact incidence, severity, and mechanisms of SD induced by psychotropic treatments.
  • Further investigation is required to establish clear causal links and effective management strategies for psychotropic-induced sexual dysfunction.
  • Differentiating drug effects from patient-specific factors is crucial for accurate assessment and treatment.