Related Experiment Video
Updated: Apr 30, 2026
Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
Published on: January 28, 2020
The Correlation between High-Sensitivity C-Reactive Protein (hsCRP) Serum Levels and Severity of Coronary
1Department of Cardiology, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.
Insights
High-sensitivity C-reactive protein (hsCRP) serum levels are significantly higher in patients with moderate and severe coronary artery stenosis. This finding links elevated hsCRP to increased severity of coronary atherosclerosis.
Area of Science:
- Cardiology
- Biomarkers
- Atherosclerosis Research
Background:
- Coronary artery stenosis incidence is rising, necessitating clearer etiological understanding.
- Inconsistent reports highlight the need to investigate inflammatory markers like hsCRP.
Purpose of the Study:
- To investigate the association between serum high-sensitivity C-reactive protein (hsCRP) levels and the severity of coronary atherosclerosis.
- To clarify the role of hsCRP as a potential biomarker for coronary artery disease severity.
Main Methods:
- Cross-sectional study involving 85 patients referred to Taleghani Hospital, Iran.
- Coronary atherosclerosis severity was assessed using Gensini score and categorized as mild, moderate, or severe.
- Serum hsCRP levels were measured and classified into three tiers: < 1, 1-3, and > 3 mg/L.
Main Results:
- A significant correlation was observed between hsCRP levels and coronary atherosclerosis severity (P < 0.010).
- Patients with moderate and severe artery stenosis exhibited significantly higher hsCRP serum levels compared to those with mild stenosis.
- The majority of patients (44.7%) had hsCRP levels > 3 mg/L, with 28.2% and 37.7% showing mild and moderate stenosis, respectively.
Conclusions:
- Serum hsCRP levels show a significant relationship with the severity of coronary atherosclerosis.
- Elevated hsCRP may serve as an indicator for more severe coronary artery stenosis.
Background:
Considering the increasing incidence of coronary artery stenosis as well as its related complications, the importance of its etiology, and inconsistent reports, we aimed to determine the relationship between High-sensitivity C-reactive protein (hsCRP) serum levels and severity of coronary atherosclerosis.
Methods:
This cross-sectional study was conducted on the patients who referred to Taleghani Hospital, Tehran, Iran and met the inclusion criteria in 2011. Regarding the severity of the disease, the angiographic findings were categorized to mild (< 10), moderate (10 - 50), and severe (> 50) using the Gensini score classification. 1 mL blood sample was taken from each patient and transferred to the laboratory after clotting. After centrifugation, the serum hsCRP level was measured and classified in 3 levels of 1, 1 to 3, and more than 3 mg / L. The relationship between hsCRP serum levels and the severity of coronary atherosclerosis was analyzed using Chi-square test (N = 85, P value < 0.010).
Results:
This study was performed on 85 patients with the mean age of 55.7 ± 7.06 years. Besides, 64.7% of the participants were male. According to the results, 34.1%, 37.7%, and 28.2% of the patients experienced mild, moderate, and severe disease intensity, respectively. Moreover, the serum hsCRP levels were < 1, between1 and 3, and > 3 mg / L in 28.2%, 27.1%, and 44.7% of the patients, respectively. The hsCRP serum levels were significantly higher in the patients with moderate and severe artery stenosis compared to those with mild stenosis (P < 0.010).
Conclusions:
The hsCRP serum levels were significantly related to the severity of coronary atherosclerosis.
More Related Videos
06:57Author Spotlight: Advancing Cardiovascular Imaging - Introducing the Spatially Weighted Calcium Score for Early Disease Detection
Published on: September 22, 2023
06:16Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease
Published on: August 9, 2024
Related Concept Videos
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
01:25Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT
01:30Coronary Artery Disease I: Introduction
01:30Acute Coronary Syndrome III: Diagnostic Studies
01:27Atherosclerosis II: Clinical Manifestations and Diagnostic Tests
01:26Coronary Artery Disease IV: Preventive Measures