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Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists
Published on: November 15, 2013
Enantioselective synthesis of PPAR (peroxisome proliferator-activated receptors) agonists and antagonists
Pilar Goya, Ruth Perez-Fernandez, Rosario Gonzalez-Muniz
1Instituto de Quimica Medica, Juan de la Cierva 3, 28006 Madrid, Spain. pgoya@iqm.csic.es.
Abstract:
This review deals with stereoselective issues in PPAR ligands some of which are in clinical use for treating certain metabolic disorders. After a short introduction of these nuclear receptor and their agonists, some cases of enantioselective separations are reported. The main part concerns stereoselective synthesis first starting with asymmetric synthesis from chiral precursors followed by what we refer to as "true" enantioselective methods. Some examples are discussed in detail for each particular heading.
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