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Related Experiment Video

Updated: Apr 30, 2026

Author Spotlight: Accelerating Diagnostic Accuracy with Direct Identification of Gram-Negatives from Blood Culture Bottles
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A cost-effective interdisciplinary approach to microbiologic send-out test use.

Scott W Aesif1, David M Parenti, Linda Lesky

  • 1From the Department of Pathology (Drs Aesif and Keiser), and the Divisions of Infectious Diseases (Dr Parenti) and Hospital Medicine (Dr Lesky), Department of Medicine, The George Washington University, Washington, DC.

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|April 25, 2014
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Summary
This summary is machine-generated.

Clinical pathology house staff screening of microbiology send-out tests reduced cancellations by 38%. Direct consultation with clinicians proved effective in managing test utilization and cutting costs.

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Area of Science:

  • Clinical Pathology
  • Medical Laboratory Science
  • Health Economics

Background:

  • Reference laboratory testing (send-out tests) incurs substantial costs in clinical laboratories.
  • Increasing use of complex molecular diagnostics necessitates cost-reduction strategies for high-value healthcare.

Purpose of the Study:

  • To implement and evaluate a strategy for optimizing microbiologic send-out test utilization.
  • To involve clinical pathology house staff and hospital clinicians in cost-effective test management.

Main Methods:

  • A 370-bed academic hospital screened all microbiologic send-out test requisitions in 2012.
  • Clinical pathology house staff reviewed tests for utility, consulting with ordering clinicians on questionable requests.
  • Interdisciplinary rounds and direct consultations were used to address test indications.

Main Results:

  • A 38% cancellation rate of send-out tests was achieved through screening, leading to cost savings.
  • Nucleic acid tests were frequently screened and represented the largest proportion of cost savings.
  • Lack of clinical indication was the primary reason for test cancellation after consultation.

Conclusions:

  • Direct, face-to-face consultation between pathology staff and clinicians is effective.
  • This interdisciplinary approach successfully manages send-out testing in microbiology.
  • The strategy supports cost-effective medicine through optimized laboratory test utilization.