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Updated: Apr 30, 2026

Fetal Echocardiography and Pulsed-wave Doppler Ultrasound in a Rabbit Model of Intrauterine Growth Restriction
Published on: June 29, 2013
[Complications due to malnutrition and intrauterine growth restriction in preterm newborns]
Mayra Patricia Arteaga-Mancera1, Mario Enrique Rendón-Macías, José Iglesias-Leboreiro
1Facultad Mexicana de Medicina, Universidad La Salle, Distrito Federal, México. mario.rendon@imss.gob.mx.
Insights
Preterm infants diagnosed with intrauterine growth restriction (IUGR) and malnutrition at birth face increased neonatal complications. Early identification and management of these conditions are crucial for improving infant outcomes.
Area of Science:
- Neonatology
- Perinatal Medicine
- Pediatric Nutrition
Context:
- Preterm infants are at higher risk for neonatal complications.
- Intrauterine growth restriction (IUGR) and malnutrition are significant concerns in high-risk pregnancies.
- Understanding the combined impact of IUGR and malnutrition on preterm neonates is critical for clinical practice.
Purpose:
- To investigate the association between intrauterine growth restriction (IUGR) and/or malnutrition at birth and the incidence of neonatal complications in preterm infants.
- To compare neonatal outcomes across different categories of preterm infants based on IUGR and nutritional status at birth.
Summary:
- This study analyzed four cohorts of preterm infants, categorizing them by the presence or absence of IUGR and malnutrition at birth.
- Neonatal morbidities and hospital stay were assessed. Results indicated that infants with IUGR, particularly those also malnourished, experienced more complications.
- While IUGR infants had longer hospital stays, nutritional status did not significantly alter this duration.
Impact:
- The findings highlight that significant growth impairments, specifically malnutrition in preterm infants diagnosed with IUGR, elevate the risk of neonatal complications.
- This underscores the importance of nutritional assessment and intervention in preterm infants with IUGR.
- Improved understanding can guide targeted clinical management strategies to mitigate adverse neonatal outcomes.
Background:
To analyze neonatal complications in preterm infants with or without previous diagnosis of intrauterine growth restriction (IUGR) and malnutrition at birth.
Methods:
We integrated four preterm cohorts: IUGR and malnourished at birth (n = 24), IUGR without malnutrition (n = 22), without IUGR and malnourished (n = 43), and with proper weight without IUGR (n = 224). Nutritional status was determined by weighted index adjusted for weeks of gestation and fetal ultrasound IUGR. Apgar, type of resuscitation, neonatal morbidities, and hospital days of stay were analyzed at birth.
Results:
Malnutrition was observed more frequently in infants with preeclamptic or eclamptic mothers, or in multiple pregnancies. There were no differences in birth conditions between groups. There were more complications in cohorts of infants with IUGR, but even more if they had malnutrition as well. Infants with IUGR adjusted for gestational age had more days of hospital stay, without differences regarding their nutritional status.
Conclusions:
In preterm infants, important growth impairments at birth (malnutrition) after being diagnosed with IUGR increase the likelihood of neonatal complications.
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