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Neutrophil activation by recombinant cytokines
1Department of Veterinary Microbiology, Preventive Medicine, Iowa State University, Ames 50011.
Reviews of Infectious Diseases
|July 1, 1989
Summary
Recombinant cytokines, such as interleukins and interferons, enhance neutrophil immune responses against pathogens. These cytokines also show potential in improving neutrophil function in immunosuppressed individuals.
Area of Science:
- Immunology
- Biotechnology
- Infectious Disease
Background:
- Recombinant cytokines are increasingly studied for their role in immunotherapy.
- Neutrophils are key effector cells in host defense against disease.
Purpose of the Study:
- To review the in vitro and in vivo activation of neutrophils by recombinant cytokines.
- To explore the potential of cytokines in enhancing neutrophil function, particularly in immunosuppressed states.
Main Methods:
- Literature review focusing on studies utilizing recombinant cytokines.
- Analysis of data on cytokine-mediated neutrophil activation and function.
Main Results:
- Various recombinant cytokines (CSFs, ILs, TNFs, IFNs) directly and synergistically activate neutrophils.
- Activated neutrophils exhibit enhanced cytocidal activity against microbial and cellular targets.
- Cytokines can improve the function of neutrophils from immunosuppressed animals, which typically have depressed function.
Conclusions:
- Recombinant cytokines represent a promising approach for enhancing neutrophil-mediated immunity.
- Further research is needed to fully understand cytokine influences on neutrophils from immunosuppressed hosts.