Related Experiment Video
Updated: Apr 30, 2026
Glioblastoma Relapse Post-Resection Model for Therapeutic Hydrogel Investigations
Published on: February 24, 2023
Considering iatrogenic psychosis after malignant glioma resection
Ashish Harish Shah1, Catherine E Gordon, Amade Bregy
1Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA.
Abstract:
It is generally well known that medial temporal lobe resections have been associated with a variety of postoperative neuropsychiatric disturbances. Most of the neurosurgical literature on psychiatric disturbances after a temporal lobectomy concern patients with a strong history of epilepsy; however, relatively few articles have been reported due to a mesial temporal lobectomy following tumour removal. We report the case of a patient who underwent a gross total resection of a malignant astrocytoma in the temporal lobe who developed transient psychosis. Difficulties in diagnosing and predicting this condition are discussed as along with management considerations.
Insights
Medial temporal lobe resections can cause neuropsychiatric issues. This case highlights transient psychosis after malignant astrocytoma removal, emphasizing diagnostic and management challenges.
Area of Science:
- Neurosurgery
- Neuropsychiatry
- Neuro-oncology
Background:
- Medial temporal lobe resections are linked to neuropsychiatric disturbances.
- Literature primarily focuses on epilepsy patients, with less on tumor removal.
Observation:
- A patient underwent resection of a temporal lobe malignant astrocytoma.
- The patient developed transient psychosis post-surgery.
Findings:
- Post-temporal lobectomy psychosis is uncommon after tumor removal.
- Challenges exist in diagnosing and predicting this neuropsychiatric complication.
Implications:
- This case underscores the need for awareness of potential psychosis after temporal lobe tumor resection.
- Improved diagnostic and management strategies are needed for these rare postoperative complications.
