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Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
Prevalence of cardiovascular risk factors in hemodialysis patients - The CORDIAL study
Jayme Eduardo Burmeister1, Camila Borges Mosmann2, Veridiana Borges Costa3
1Programa de Pós-graduação em Ciências da Saúde, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, RS, Brasil.
Insights
Chronic hemodialysis patients in Brazil exhibit a high prevalence of cardiovascular risk factors, including hypertension and dyslipidemia. These findings highlight the urgent need for targeted interventions to mitigate cardiovascular disease in this vulnerable population.
Area of Science:
- Cardiology
- Nephrology
- Epidemiology
Background:
- Limited epidemiological data exists on the cardiovascular risk profile of chronic hemodialysis patients in Brazil.
- The CORDIAL study addresses this gap by investigating cardiovascular risk factors in a Brazilian hemodialysis population.
Purpose of the Study:
- To evaluate the cardiovascular risk profile of patients undergoing chronic hemodialysis in a major Brazilian metropolitan area.
- To identify prevalent cardiovascular risk factors and their associations within this patient cohort.
Main Methods:
- The CORDIAL study enrolled 1215 patients from all fifteen nephrology centers in Porto Alegre, Brazil.
- Data collection involved reviewing medical records and conducting structured interviews to gather clinical, laboratory, and demographic information.
Main Results:
- A high prevalence of cardiovascular risk factors was observed: hypertension (87.5%), dyslipidemia (84.7%), sedentary lifestyle (73.1%), tobacco use (53.7%), and diabetes (35.8%).
- Sedentary lifestyle, dyslipidemia, and obesity were more common in women, while hypertension and tobacco use were more prevalent in patients under 65.
- Sedentary lifestyle was independently associated with a dialysis duration of less than 12 months.
Conclusions:
- Hemodialysis patients in this Brazilian metropolitan city present a high burden of cardiovascular risk factors.
- The observed risk profile resembles that found in hemodialysis populations in many northern countries, indicating a need for comparable preventive strategies.
Background:
There are scarce epidemiological data on cardiovascular risk profile of chronic hemodialysis patients in Brazil.
Objective:
The CORDIAL study was designed to evaluate cardiovascular risk factors and follow up a hemodialysis population in a Brazilian metropolitan city.
Methods:
All patients undergoing regular hemodialysis for chronic renal failure in all fifteen nephrology centers of Porto Alegre were considered for inclusion in the baseline phase of the CORDIAL study. Clinical, laboratory and demographic data were obtained in medical records and in structured individual interviews performed in all patients by trained researchers.
Results:
A total of 1215 patients were included (97.3% of all hemodialysis patients in the city of Porto Alegre). Their average age was 58.3 years old, 59.5% were male and 62.8% were white. The prevalence of cardiovascular risk factors observed was 87.5% for hypertension, 84.7% for dyslipidemia, 73.1% for sedentary lifestyle, 53.7% for tobacco use, and 35.8% for diabetes. In a multivariate adjusted analysis, we found that sedentary lifestyle (p = 0.032, PR 1.08 - 95%CI: 1.01-1.15), dyslipidemia (p = 0.019, PR 1.08 - 95%CI: 1.01-1.14), and obesity (p < 0.001, PR 1.96 - 95%CI: 1.45-2.63) were more frequent in women; and hypertension (p = 0.018, PR 1.06 - 95%CI: 1.01-1.11) and tobacco use (p = 0.006, PR 2.7 - 95%CI: 1.79-4.17) were more often found among patients under 65 years old. Sedentary lifestyle was independently associated with time in dialysis less than 12 months (p < 0.001, PR 1.23 - 95% CI: 1.14-1.33).
Conclusion:
Hemodialysis patients in this southern metropolitan Brazilian city have a high prevalence of cardiovascular risk factors resembling many northern countries.
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