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Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells
Published on: August 25, 2021
Krukenberg tumour as the initial presentation of Peutz-Jeghers syndrome
Bhavith Remalayam1, Santhosh Kuriakose, Prathapan Valiya Kambarath
1Department of Gastroenterology, Government Medical College, Kozhikode, Kerala, India, Department of Obstetrics and Gynaecology, Government Medical College, Kozhikode, Kerala, India and Department of Surgical Gastroenterology, Government Medical College, Kozhikode, Kerala, India.
Abstract:
Peutz-Jeghers syndrome (PJS) is an hereditary syndrome characterized by gastrointestinal polyposis and mucocutaneous pigmentation. PJS patients are at increased risk of developing various cancers, especially of the gastrointestinal and gynaecological tracts. Colonic adenocarcinoma is one of the more common tumours that occur in PJS. We report a young lady presenting with a large ovarian tumour, later diagnosed to have PJS with colonic signet cell adenocarcinoma and synchronous ovarian metastasis.
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