Immunogold-silver labeling in histology

Immunogold-silver staining is a relatively new technique in light-microscopic immunocytochemistry. It is based on silver enhancement of 1 to 10 nm gold probes immunologically bound to antigenic determinants in tissue sections. The detection efficiency of this third-generation detection technique is compared to that of the peroxidase-based ABC technique in routinely processed, paraffin-embedded, human biopsy material.