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Related Experiment Videos

[The plasma histamine level during anesthesia induction using midazolam].

M Behne1, G Janshon, V Lischke

  • 1Zentrum der Anaesthesiologie und Wiederbelebung der Johann Wolfgang Goethe-Universität Frankfurt/Main.

Der Anaesthesist
|July 1, 1989
PubMed
Summary
This summary is machine-generated.

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Midazolam does not trigger histamine release in patients. This study found no evidence of histamine release following midazolam injection, suggesting it is safe in this regard.

Area of Science:

  • Pharmacology
  • Anesthesiology

Background:

  • Histamine release is a potential adverse effect of some anesthetic agents.
  • Midazolam's potential as a histamine releaser has not been previously studied.

Purpose of the Study:

  • To investigate whether intravenous midazolam administration causes histamine release.
  • To determine the safety profile of midazolam concerning histamine release.

Main Methods:

  • A randomized study involving 20 patients.
  • Intravenous injection of midazolam (0.15 mg/kg) or saline (0.15 ml/kg).
  • Plasma histamine levels measured by HPLC at baseline and post-injection (2, 5, 10 minutes).

Main Results:

  • Midazolam administration did not lead to increased plasma histamine levels.

Related Experiment Videos

  • Histamine levels showed a slight decrease in the midazolam group (P<0.05).
  • No typical histamine release kinetics were observed; minor hemodynamic changes did not correlate with histamine levels.

    • Conclusions:

    • Midazolam is not a histamine-releasing drug.
    • The study did not find evidence linking midazolam to histamine release.