Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mass Spectrometry: Alkyl Halide Fragmentation01:22

Mass Spectrometry: Alkyl Halide Fragmentation

1.5K
Chlorine isotopes exist as 35Cl and 37Cl in a 3:1 ratio, while bromine isotopes exist as 79Br and 81Br in a 1:1 ratio. The mass spectrum of alkyl halides typically produces two distinct molecular ion peaks, the molecular ion peak, [M], and the molecular ion plus two, [M + 2] peak. The relative heights of these two peaks are proportional to the isotopic abundance ratios of the halide. For example, 2‐chloropropane and 1‐bromopropane display two peaks with relative peak heights in a 3:1 and...
1.5K
Halogenation of Alkenes02:46

Halogenation of Alkenes

17.1K
Halogenation is the addition of chlorine or bromine across the double bond in an alkene to yield a vicinal dihalide. The reaction occurs in the presence of inert and non-nucleophilic solvents, such as methylene chloride, chloroform, or carbon tetrachloride.
Consider the bromination of cyclopentene. Molecular bromine is polarized in the proximity of the π electrons of cyclopentene. An electrophilic bromine atom adds across the double bond, forming a cyclic bromonium ion intermediate.
17.1K
Electrophilic Addition to Alkynes: Halogenation02:38

Electrophilic Addition to Alkynes: Halogenation

7.4K
Introduction
Halogenation is another class of electrophilic addition reactions where a halogen molecule gets added across a π bond. In alkynes, the presence of two π bonds allows for the addition of two equivalents of halogens (bromine or chlorine). The addition of the first halogen molecule forms a trans-dihaloalkene as the major product and the cis isomer as the minor product. Subsequent addition of the second equivalent yields the tetrahalide.
7.4K
Halogens03:01

Halogens

17.2K
Group 17 elements, known as halogens, are nonmetals. At room temperature, fluorine and chlorine are gases, bromine is a liquid, and iodine a solid. Astatine is a highly unstable radioactive element, so currently, most of its properties are unknown due to its short half-life. Tennessine is a synthetic element also predicted to be in this group. 
17.2K
Alkyl Halides02:45

Alkyl Halides

16.8K
Structural Properties
Alkyl halides are halogen-substituted alkanes wherein one or more hydrogen atoms of an alkane is replaced by a halogen atom such as fluorine, chlorine, bromine, or iodine. The carbon atom in an alkyl halide is bonded to the halogen atom, which is sp3-hybridized and exhibits a tetrahedral shape.
Unlike alkyl halides, compounds in which a halogen atom is bonded to an sp2 -hybridized carbon atom of a carbon-carbon double bond (C=C) are called vinyl halides. Whereas aryl...
16.8K
Electrophilic 1,2- and 1,4-Addition of X2 to 1,3-Butadiene01:14

Electrophilic 1,2- and 1,4-Addition of X2 to 1,3-Butadiene

2.7K
Electrophilic addition of halogens to alkenes proceeds via a cyclic halonium ion to form a 1,2-dihalide or a vicinal dihalide.
2.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of shared facilities in advancing solid-state NMR research: 2025 edition.

Solid state nuclear magnetic resonance·2025
Same author

NMR Crystallographic Journey from Light to Heavy Atoms of Mercury(II)-DOTAM Complexes and Extraction of Related Structural Parameters.

Inorganic chemistry·2025
Same author

Isotopic Identification of Quadrupolar Spin Resonance Lines by Zeeman Perturbation.

The journal of physical chemistry letters·2025
Same author

Understanding Non-Covalent Interactions in Diphenyldiselenide and Diphenylselenide Cocrystals Using a Combined <sup>77</sup>Se Magic-Angle Spinning Solid-State NMR and Quantum Chemical Analysis Approach.

The journal of physical chemistry. C, Nanomaterials and interfaces·2025
Same author

NMR Crystallographic Investigation Coupled with Molecular Dynamics Simulations Reveals the Nature of Disorder in Chlorpromazine Hydrochloride Solvatomorphs.

Molecular pharmaceutics·2025
Same author

Practical aspects of Zeeman-perturbed NQR spectroscopy using an adjustable electromagnet.

Solid state nuclear magnetic resonance·2025

Related Experiment Video

Updated: Apr 30, 2026

From Molecules to Materials: Engineering New Ionic Liquid Crystals Through Halogen Bonding
06:44

From Molecules to Materials: Engineering New Ionic Liquid Crystals Through Halogen Bonding

Published on: March 24, 2018

71.2K

Solid-state NMR study of halogen-bonded adducts.

David L Bryce1, Jasmine Viger-Gravel

  • 1Department of Chemistry, University of Ottawa, Ottawa, ON, Canada, David.Bryce@uottawa.ca.

Topics in Current Chemistry
|April 25, 2014
PubMed
Summary

Nuclear magnetic resonance (NMR) spectroscopy reveals details about halogen bonds. Solid-state NMR experiments offer advantages for studying these interactions, providing insights into their structure and geometry.

Area of Science:

  • Solid-state chemistry
  • Spectroscopy
  • Supramolecular chemistry

Background:

  • Halogen bonds are crucial non-covalent interactions.
  • Nuclear magnetic resonance (NMR) spectroscopy is a powerful tool for molecular structure determination.
  • Understanding halogen bond dynamics and structure is essential in various chemical fields.

Purpose of the Study:

  • To provide an overview of NMR interactions and experiments relevant to studying halogen bonds.
  • To highlight the advantages of solid-state NMR for halogen bond analysis.
  • To discuss the sensitivity of NMR parameters to halogen bond geometry.

Main Methods:

  • Solid-state Nuclear Magnetic Resonance (NMR) spectroscopy.
  • Analysis of NMR parameters including chemical shifts, quadrupolar coupling constants, and J coupling constants.

More Related Videos

Atomic Scale Structural Studies of Macromolecular Assemblies by Solid-state Nuclear Magnetic Resonance Spectroscopy
14:55

Atomic Scale Structural Studies of Macromolecular Assemblies by Solid-state Nuclear Magnetic Resonance Spectroscopy

Published on: September 17, 2017

16.8K
Imine Metathesis by Silica-Supported Catalysts Using the Methodology of Surface Organometallic Chemistry
09:37

Imine Metathesis by Silica-Supported Catalysts Using the Methodology of Surface Organometallic Chemistry

Published on: October 18, 2019

10.0K

Related Experiment Videos

Last Updated: Apr 30, 2026

From Molecules to Materials: Engineering New Ionic Liquid Crystals Through Halogen Bonding
06:44

From Molecules to Materials: Engineering New Ionic Liquid Crystals Through Halogen Bonding

Published on: March 24, 2018

71.2K
Atomic Scale Structural Studies of Macromolecular Assemblies by Solid-state Nuclear Magnetic Resonance Spectroscopy
14:55

Atomic Scale Structural Studies of Macromolecular Assemblies by Solid-state Nuclear Magnetic Resonance Spectroscopy

Published on: September 17, 2017

16.8K
Imine Metathesis by Silica-Supported Catalysts Using the Methodology of Surface Organometallic Chemistry
09:37

Imine Metathesis by Silica-Supported Catalysts Using the Methodology of Surface Organometallic Chemistry

Published on: October 18, 2019

10.0K
  • Experimental studies on various halogen-bonded adducts.

    • Main Results:

    • NMR parameters are sensitive to halogen bond formation and structure.
    • Solid-state NMR offers advantages over solution studies, such as the absence of solvent interference and the ability to measure complete interaction tensors.
    • Specific NMR parameters like isotropic chemical shifts, chemical shift tensor spans, and quadrupolar coupling tensors are highly sensitive to halogen bond geometry.

    Conclusions:

    • Solid-state NMR spectroscopy is a valuable technique for investigating halogen bonds.
    • NMR parameters provide detailed information about the structure and geometry of halogen bonds.
    • Further research can explore the technical limitations and applications of NMR in studying halogen-bonded systems.