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Basal cell carcinoma with hyaline inclusions.
A A Sahin1, J Y Ro, D J Grignon
1Department of Pathology, University of Texas M. D. Anderson Cancer Center, Houston 77030.
Archives of Pathology & Laboratory Medicine
|September 1, 1989
Summary
This study describes an unusual basal cell carcinoma (BCC) in a 67-year-old woman, featuring unique cytoplasmic inclusions. These inclusions, identified as filament aggregates, present diagnostic challenges for pathologists.
Area of Science:
- Dermatopathology
- Surgical Pathology
- Oncology
Background:
- Basal cell carcinoma (BCC) is the most common type of skin cancer.
- BCC typically presents with characteristic histopathological features.
- Unusual variants of BCC can pose diagnostic challenges.
Observation:
- A 67-year-old female patient presented with a basal cell carcinoma on the forehead.
- The BCC exhibited numerous hyaline cytoplasmic inclusions within the tumor cells.
- These inclusions were investigated using electron microscopy and immunohistochemistry.
Findings:
- Electron microscopy revealed the inclusions to be aggregates of cytoplasmic filaments.
- Immunohistochemical analysis showed reactivity for keratin, vimentin, and smooth-muscle myosin within these inclusions.
- The presence of these specific proteins suggests a complex cellular origin or differentiation within the tumor.
Implications:
- This unusual presentation of basal cell carcinoma requires awareness among pathologists.
- Recognition of these hyaline cytoplasmic inclusions is crucial to avoid misdiagnosis.
- Understanding the composition of these inclusions may offer insights into BCC pathogenesis.