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Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome ARDS
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Hemodynamic changes in child acute respiratory distress syndrome with airway pressure release ventilation: a case

Atsushi Kawaguchi1,2,3, Gonzalo Garcia Guerra1, Jonathan P Duff1

  • 1Department of Pediatrics, Pediatric Critical Care Medicine, Stollery Children's Hospital, University of Alberta, Edmonton, Canada.

The Clinical Respiratory Journal
|April 26, 2014
PubMed

Insights

Airway pressure release ventilation (APRV) can be safely used in pediatric acute respiratory distress syndrome (ARDS) patients. This study found no significant hemodynamic compromise or side effects in children receiving APRV.

Area of Science:

  • Pediatric Critical Care Medicine
  • Respiratory Physiology
  • Mechanical Ventilation

Background:

  • Airway pressure release ventilation (APRV) is a common mechanical ventilation strategy in adult intensive care units.
  • Limited data exists regarding the application and safety of APRV in pediatric patients.

Purpose of the Study:

  • To evaluate the safety and efficacy of APRV in pediatric patients diagnosed with acute respiratory distress syndrome (ARDS).

Main Methods:

  • Retrospective review of pediatric patients with ARDS who received APRV for at least 12 hours between 2007 and 2009.
  • Analysis of demographic data, ventilation duration, blood gas parameters, and hemodynamic parameters.

Main Results:

  • Thirteen pediatric ARDS patients were included, with a mean weight of 18.2 kg and age of 68 months.
  • APRV was used for a median of 4 days (range 1-10 days).
  • No significant changes in blood gas or hemodynamic parameters (mean arterial blood pressure, central venous pressure, heart rate) were observed during APRV use.

Conclusions:

  • APRV can be safely administered to pediatric patients with ARDS.
  • The use of APRV in this cohort did not result in significant hemodynamic compromise or adverse effects.
Abstract

Keywords:
acute respiratory distress syndromeairway pressure release ventilationchildrenspontaneous breathing

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